Liberation of FFAs from IMTG stores via lipolysis in skeletal muscle during exercise occurs via the activities of HSL and ATGL. Exercise increases the utilization of lipids in muscle. The sources of lipids are long-chain fatty acids taken up In skeletal muscle, 98% of the lipase activity is accounted for by adipose triglyceride lipase and Andreas Børsting Jordy, Bente Kiens.
Emphasis is on regulation of glucose and fatty acid metabolism and the mechanisms regulating their use as fuels for the muscle during exercise. AMPK activation during exercise seems insufficient to regulate autophagosome content in muscle, while mTORC1 signalling via ULK1 probably mediates the autophagy-inhibiting effect of insulin. However, little is known about the regulation of autophagy in human skeletal muscle. Bente Kiens1 Skeletal muscle remains more sensitive to insulin for 24-48 h after exercise in both rodents (1,5) and humans (3,6,7).